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In-Vitro Maturation
What is IVM?
Often seen as an alternative to IVF, IVM or In-Vitro Maturation is an infertility treatment in which the female partner’s eggs are matured outside her body. The immature eggs are obtained without stimulating the patient’s ovaries. These are then matured artificially in labs and the process is continued as a regular IVF treatment. As ovaries aren’t required to be stimulated in IVM, the patient has to intake a lot less hormonal medications, making it the treatment of choice of patients eligible for it.
For which patients is IVM recommended?
In-Vitro Maturation is primarily preferred for patients with PCOS who are at most risk of ovarian hyperstimulation syndrome (OHSS). OHSS is an exaggerated response to medicines used to induce ovulation. With a negligible number of medicines required to intake in IVM, it becomes suitable for patients with PCOS or PCO-like ovaries. IVM is also recommended for patients with cancer (especially estrogen-sensitive cancers) and those who require rapid fertility preservation before beginning potentially gonadotoxic treatments
What are the success rates with IVM?
IVM is typically 50% less effective than IVF. This implies that if a woman has a 50% chance of getting pregnant with IVF, she will have 25% with IVM.
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Differences between IVM and IVF:
| IVM | IVF |
|---|---|
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Immature eggs are retrieved
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Mature eggs are retrieved
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Safer than IVF
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Less safer than IVM
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Negligible hormonal medicines needed to ingest
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Considerable number of hormonal medicines needed to ingest
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Less expensive than IVF
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Comparatively more expensive
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50% less successful than IVF
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50% more successful than IVM
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